CNOT4
CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[5]
Function
The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.[6]
References
- GRCh38: Ensembl release 89: ENSG00000080802 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000038784 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: CCR4-NOT transcription complex, subunit 4".
- "CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.
Further reading
- Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal. 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038. S2CID 25618632.
- Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
- Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits" (PDF). The Biochemical Journal. 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
- Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
- Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure. 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
- Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
- Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development. 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
- Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry. 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
- Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
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