CNOT4

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[5]

CNOT4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDsOMIM: 604911 MGI: 1859026 HomoloGene: 40870 GeneCards: CNOT4
Orthologs
SpeciesHumanMouse
Entrez

4850

53621

Ensembl

ENSG00000080802

ENSMUSG00000038784

UniProt

O95628

Q8BT14

RefSeq (mRNA)

NM_001164411
NM_001164412
NM_001164413
NM_001164414
NM_016877

RefSeq (protein)

NP_001157883
NP_001157884
NP_001157885
NP_001157886
NP_058573

Location (UCSC)Chr 7: 135.36 – 135.51 MbChr 6: 35 – 35.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000080802 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038784 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CCR4-NOT transcription complex, subunit 4".
  6. "CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.