CNOT6

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.[5][6]

CNOT6
Identifiers
AliasesCNOT6, CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6
External IDsOMIM: 608951 MGI: 2144529 HomoloGene: 69187 GeneCards: CNOT6
Orthologs
SpeciesHumanMouse
Entrez

57472

104625

Ensembl

ENSG00000113300

ENSMUSG00000020362

UniProt

Q9ULM6

Q8K3P5

RefSeq (mRNA)

NM_001303241
NM_015455
NM_001370472
NM_001370473
NM_001370474

NM_001290741
NM_212484
NM_001363356
NM_001363357

RefSeq (protein)

NP_001290170
NP_001357401
NP_001357402
NP_001357403

NP_001277670
NP_997649
NP_001350285
NP_001350286

Location (UCSC)Chr 5: 180.49 – 180.58 MbChr 11: 49.56 – 49.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000113300 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020362 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen J, Chiang YC, Denis CL (Mar 2002). "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase". EMBO J. 21 (6): 1414–26. doi:10.1093/emboj/21.6.1414. PMC 125924. PMID 11889047.
  6. "Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6".

Further reading


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