CNOT8

CNOT8
Identifiers
Aliases	CNOT8, CAF1, CALIF, Caf1b, POP2, hCAF1, CCR4-NOT transcription complex subunit 8
External IDs	OMIM: 603731 MGI: 1916375 HomoloGene: 48304 GeneCards: CNOT8
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	154,876,792 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	58,009,420 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; monocyte; ; sperm; ; right lung; ; ganglionic eminence; ; Achilles tendon; ; rectum; ; upper lobe of left lung; ; synovial joint; ; lymph node;
	Top expressed in
	secondary oocyte; ; thymus; ; medial ganglionic eminence; ; neural tube; ; morula; ; superior frontal gyrus; ; utricle; ; cerebellar cortex; ; lip; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; 3'-5'-exoribonuclease activity; DNA-binding transcription factor activity; metal ion binding; protein binding; RNA binding; nucleic acid binding; nuclease activity; exonuclease activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; CCR4-NOT complex; intracellular anatomical structure; nucleus; P-body; CCR4-NOT core complex;
Biological process	regulation of transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; positive regulation of mRNA catabolic process; transcription, DNA-templated; gene silencing by miRNA; positive regulation of cell population proliferation; exonucleolytic catabolism of deadenylated mRNA; gene silencing; regulation of translation; negative regulation of cell population proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	9337
	69125
	ENSG00000155508
	ENSMUSG00000020515
	Q9UFF9
	Q9D8X5
NM_001301073; NM_001301074; NM_001301075; NM_001301077; NM_001301080;
	NM_001301082; NM_001301083; NM_001301086; NM_004779
	NM_026949; NM_001356477; NM_001363084; NM_001363085; NM_001363086
NP_001288002; NP_001288003; NP_001288004; NP_001288006; NP_001288009;
	NP_001288011; NP_001288012; NP_001288015; NP_004770
	NP_081225; NP_001343406; NP_001350013; NP_001350014; NP_001350015
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene.[5][6][7] It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT8 has been shown to interact with BTG2,[8] BTG1,[8][9] CNOT1[6][10] and CNOT3.[6]

References

GRCh38: Ensembl release 89: ENSG00000155508 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020515 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fidler C, Wainscoat JS, Boultwood J (May 1999). "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome". Genomics. 56 (1): 134–6. doi:10.1006/geno.1998.5687. PMID 10036195.
Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
"Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8".
Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

Human CNOT8 genome location and CNOT8 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155508 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020515 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10036195-5] Fidler C, Wainscoat JS, Boultwood J (May 1999). "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome". Genomics. 56 (1): 134–6. doi:10.1006/geno.1998.5687. PMID 10036195.

[pmid10637334-6] Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

[entrez-7] "Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8".

[pmid11136725-8] Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.

[pmid16189514-9] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid17353931-10] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

CNOT8

Interactions

References

Further reading

External links