CNOT9
CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene. [5]
Function
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].
References
- GRCh38: Ensembl release 89: ENSG00000144580 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000026174 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: CCR4-NOT transcription complex subunit 9". Retrieved 2020-04-15.
Further reading
- Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, Okayama H (October 2002). "Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation". EMBO J. 21 (19): 5235–44. doi:10.1093/emboj/cdf521. PMC 129043. PMID 12356739.
- Garapaty S, Mahajan MA, Samuels HH (March 2008). "Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1". J. Biol. Chem. 283 (11): 6806–16. doi:10.1074/jbc.M706986200. PMID 18180299.
- Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T, Daigo Y, Nakamura Y (October 2009). "Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells". Int. J. Oncol. 35 (4): 673–81. PMID 19724902.
- Ajiro M, Nishidate T, Katagiri T, Nakamura Y (November 2010). "Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis". Int. J. Oncol. 37 (5): 1085–93. doi:10.3892/ijo_00000760. PMID 20878056.
- Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W (June 2014). "Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression". Mol. Cell. 54 (5): 751–65. doi:10.1016/j.molcel.2014.03.036. PMID 24768538.
- Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E (June 2014). "A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing". Mol. Cell. 54 (5): 737–50. doi:10.1016/j.molcel.2014.03.034. PMID 24768540.
- Wong SQ, Behren A, Mar VJ, Woods K, Li J, Martin C, Sheppard KE, Wolfe R, Kelly J, Cebon J, Dobrovic A, McArthur GA (January 2015). "Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma". Oncotarget. 6 (2): 1115–27. doi:10.18632/oncotarget.2747. PMC 4359221. PMID 25544760.
- Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE (March 2018). "Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment" (PDF). J. Mol. Biol. 430 (5): 722–736. doi:10.1016/j.jmb.2017.12.018. PMID 29291391.
- Han J, Yu J, Dai Y, Li J, Guo M, Song J, Zhou X (February 2019). "Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway". Bosn J Basic Med Sci. 19 (1): 52–59. doi:10.17305/bjbms.2018.3399. PMC 6387672. PMID 29924958.
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