Contactin 1

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.[5][6]

CNTN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNTN1, F3, GP135, MYPCN, contactin 1
External IDsOMIM: 600016 MGI: 105980 HomoloGene: 7274 GeneCards: CNTN1
Orthologs
SpeciesHumanMouse
Entrez

1272

12805

Ensembl

ENSG00000018236

ENSMUSG00000055022

UniProt

Q12860

P12960

RefSeq (mRNA)

NM_001256063
NM_001256064
NM_001843
NM_175038

NM_001159647
NM_001159648
NM_007727
NM_001358051

RefSeq (protein)

NP_001242992
NP_001242993
NP_001834
NP_778203

NP_001153119
NP_001153120
NP_031753
NP_001344980

Location (UCSC)Chr 12: 40.69 – 41.07 MbChr 15: 91.95 – 92.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[6]

Interactions

CNTN1 has been shown to interact with PTPRB.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000018236 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055022 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12". Genomics. 21 (3): 571–82. doi:10.1006/geno.1994.1316. PMID 7959734.
  6. "Entrez Gene: CNTN1 contactin 1".
  7. Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". The Journal of Cell Biology. 136 (4): 907–18. doi:10.1083/jcb.136.4.907. PMC 2132488. PMID 9049255.
  8. Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J (Jul 1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin". Cell. 82 (2): 251–60. doi:10.1016/0092-8674(95)90312-7. PMID 7628014. S2CID 18084292.

Further reading

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