COAT platelet defect

A collagen- and thrombin-activated (COAT) platelet defect is a platelet function disorder that is due to a reduced ability to generate procoagulant platelets. It is associated with a clinically relevant bleeding phenotype.

During physiological platelet activation, a fraction of platelets expresses phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation. These so-called COAT platelets, can be generated by dual-agonist stimulation with collagen and thrombin in a laboratory setting. COAT platelet defects should be distinguished from Scott syndrome, a rare bleeding disorder in which patients have impaired phospholipid scrambling and do not express negatively charged phospholipids on their surface even after treatment with calcium ionophores.[1]

References

Aliotta, A; Alberio, L (Feb 24, 2021). "Thrombocytopathies: Not Just Aggregation Defects - The clinical relevance of Procoagulant Platelets". J Clin Med. 10 (5): 894. doi:10.3390/jcm10050894. PMC 7956450. PMID 33668091. This article incorporates text available under the CC BY 4.0 license.

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[1] Aliotta, A; Alberio, L (Feb 24, 2021). "Thrombocytopathies: Not Just Aggregation Defects - The clinical relevance of Procoagulant Platelets". J Clin Med. 10 (5): 894. doi:10.3390/jcm10050894. PMC 7956450. PMID 33668091. This article incorporates text available under the CC BY 4.0 license.