COMMD3-BMI1

COMMD3-BMI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H0D, 3RPG, 4R8P
Identifiers
Aliases	COMMD3-BMI1, COMMD3-BMI1 readthrough, BMI1, RNF51, PCGF4
External IDs	MGI: 88174 HomoloGene: 3797 GeneCards: COMMD3-BMI1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	22,329,542 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	18,691,440 bp[2]
RNA expression pattern
	Top expressed in
	corpus callosum; ; islet of Langerhans; ; bone marrow cells; ; sural nerve; ; stromal cell of endometrium; ; duodenum; ; Achilles tendon; ; thymus; ; appendix; ; ganglionic eminence;
	Top expressed in
	secondary oocyte; ; plantaris muscle; ; extensor digitorum longus muscle; ; superior surface of tongue; ; medial ganglionic eminence; ; interventricular septum; ; gallbladder; ; retinal pigment epithelium; ; atrioventricular valve; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	promoter-specific chromatin binding; RING-like zinc finger domain binding; metal ion binding; protein binding; zinc ion binding;
Cellular component	cytoplasm; ubiquitin ligase complex; nucleoplasm; PRC1 complex; PcG protein complex; nucleus; cytosol; nuclear body;
Biological process	regulation of transcription, DNA-templated; positive regulation of fibroblast proliferation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; segment specification; negative regulation of gene expression, epigenetic; positive regulation of ubiquitin-protein transferase activity; regulation of gene expression; histone H2A-K119 monoubiquitination; negative regulation of G0 to G1 transition; chromatin organization; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	100532731
	12151
	ENSG00000269897
	ENSMUSG00000026739
	P35226
	P25916
	NM_001204062
	NM_007552
	NP_001190991; NP_005171
	NP_031578
	Wikidata
View/Edit Human	View/Edit Mouse

The COMMD3-BMI1 gene in humans encodes the COMMD3-BMI1 readthrough protein. [5]

Function

This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.[6]

References

GRCh38: Ensembl release 89: ENSG00000269897 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026739 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: COMMD3-BMI1 readthrough". Retrieved 2013-10-05.
[provided by RefSeq, Feb 2011].

COMMD3-BMI1

Function

References

Further reading