COX7A1

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.[5][6][7]

COX7A1
Identifiers
AliasesCOX7A1, COX7A, COX7AH, COX7AM, cytochrome c oxidase subunit 7A1
External IDsOMIM: 123995 MGI: 1316714 HomoloGene: 48051 GeneCards: COX7A1
Orthologs
SpeciesHumanMouse
Entrez

1346

12865

Ensembl

ENSG00000161281

ENSMUSG00000074218

UniProt

P24310

P56392

RefSeq (mRNA)

NM_001864

NM_009944

RefSeq (protein)

NP_001855

NP_034074

Location (UCSC)Chr 19: 36.15 – 36.15 MbChr 7: 29.88 – 29.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000161281 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074218 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.
  6. Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA (Oct 1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase". Nucleic Acids Res. 17 (17): 7107. doi:10.1093/nar/17.17.7107. PMC 318441. PMID 2550906.
  7. "Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)".

Further reading


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