COX7A2L

Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.[5][6]

COX7A2L
Identifiers
Aliases	COX7A2L, COX7AR, COX7RP, EB1, SIG81, cytochrome c oxidase subunit 7A2 like, SCAFI, SCAF1
External IDs	OMIM: 605771 MGI: 106015 HomoloGene: 3463 GeneCards: COX7A2L
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 42,333,546 bp[1] End 42,425,088 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 83,809,347 bp[2] End 83,824,759 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Achilles tendon left adrenal gland islet of Langerhans middle temporal gyrus amniotic fluid secondary oocyte Brodmann area 23 nucleus accumbens ovary Top expressed in spleen ganglionic eminence uterus bone marrow pancreas thymus islet of Langerhans duodenum mirror urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity cytochrome-c oxidase activity Cellular component mitochondrial inner membrane membrane mitochondrial respirasome nucleolus mitochondrion Biological process proton transmembrane transport electron transport chain regulation of oxidative phosphorylation mitochondrial respirasome assembly mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9167 20463 Ensembl ENSG00000115944 ENSMUSG00000024248 UniProt O14548 Q61387 RefSeq (mRNA) NM_004718 NM_001319036 NM_001319037 NM_001319038 NM_001319040 NM_001159529 NM_009187 RefSeq (protein) NP_001305965 NP_001305966 NP_001305967 NP_001305969 NP_004709 NP_001153001 NP_033213 Location (UCSC) Chr 2: 42.33 – 42.43 Mb Chr 17: 83.81 – 83.82 Mb PubMed search [3] [4]
Wikidata
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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.

The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.

This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence.

This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.[6]