COX7C

Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.[3][4]

COX7C
Identifiers
AliasesCOX7C, cytochrome c oxidase subunit 7C
External IDsOMIM: 603774 HomoloGene: 135674 GeneCards: COX7C
Orthologs
SpeciesHumanMouse
Entrez

1350

n/a

Ensembl

ENSG00000127184

n/a

UniProt

P15954

n/a

RefSeq (mRNA)

NM_001867

n/a

RefSeq (protein)

NP_001858

n/a

Location (UCSC)Chr 5: 86.62 – 86.62 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.[4]

References

  1. GRCh38: Ensembl release 89: ENSG00000127184 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.
  4. "Entrez Gene: COX7C cytochrome c oxidase subunit VIIc".

Further reading


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