CPEB1

Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.[5][6]

CPEB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPEB1, CEBP, CPE-BP1, CPEB, CPEB-1, hCPEB-1, h-CPEB, cytoplasmic polyadenylation element binding protein 1
External IDsOMIM: 607342 MGI: 108442 HomoloGene: 7278 GeneCards: CPEB1
Orthologs
SpeciesHumanMouse
Entrez

64506

12877

Ensembl

ENSG00000277445
ENSG00000214575

ENSMUSG00000025586

UniProt

Q9BZB8

P70166

RefSeq (mRNA)

NM_001252525
NM_001252526
NM_007755
NM_001357107

RefSeq (protein)

NP_001239454
NP_001239455
NP_031781
NP_001344036

Location (UCSC)Chr 15: 82.54 – 82.65 MbChr 7: 81 – 81.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. ENSG00000214575 GRCh38: Ensembl release 89: ENSG00000277445, ENSG00000214575 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025586 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Welk JF, Charlesworth A, Smith GD, MacNicol AM (Mar 2001). "Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein". Gene. 263 (1–2): 113–20. doi:10.1016/S0378-1119(00)00588-6. PMID 11223249.
  6. "Entrez Gene: CPEB1 cytoplasmic polyadenylation element binding protein 1".

Further reading


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