CPLX2

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.[5][6][7]

CPLX2
Identifiers
AliasesCPLX2, 921-L, CPX-2, CPX2, Hfb1, complexin 2
External IDsOMIM: 605033 MGI: 104726 HomoloGene: 38212 GeneCards: CPLX2
Orthologs
SpeciesHumanMouse
Entrez

10814

12890

Ensembl

ENSG00000145920

ENSMUSG00000025867

UniProt

Q6PUV4

P84086

RefSeq (mRNA)

NM_001008220
NM_006650
NM_032282

NM_009946
NM_001362218

RefSeq (protein)

NP_001008221
NP_006641

NP_034076
NP_001349147

Location (UCSC)Chr 5: 175.8 – 175.88 MbChr 13: 54.52 – 54.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000145920 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025867 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
  6. Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
  7. "Entrez Gene: CPLX2 complexin 2".

Further reading


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