CPSF1

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.[5][6][7]

CPSF1
Identifiers
AliasesCPSF1, CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1
External IDsOMIM: 606027 MGI: 2679722 HomoloGene: 40865 GeneCards: CPSF1
Orthologs
SpeciesHumanMouse
Entrez

29894

94230

Ensembl

ENSG00000071894

ENSMUSG00000034022

UniProt

Q10570

Q9EPU4

RefSeq (mRNA)

NM_013291

NM_001164173
NM_053193
NM_001361485

RefSeq (protein)

NP_037423

NP_001157645
NP_444423
NP_001348414

Location (UCSC)Chr 8: 144.39 – 144.41 MbChr 15: 76.48 – 76.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.[8]


References

  1. GRCh38: Ensembl release 89: ENSG00000071894 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034022 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jenny A, Keller W (Sep 1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor". Nucleic Acids Res. 23 (14): 2629–35. doi:10.1093/nar/23.14.2629. PMC 307085. PMID 7651824.
  6. Murthy KG, Manley JL (Dec 1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
  7. "Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa".
  8. Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL (February 2009). "Molecular architecture of the human pre-mRNA 3' processing complex". Mol. Cell. 33 (3): 365–76. doi:10.1016/j.molcel.2008.12.028. PMC 2946185. PMID 19217410.

Further reading


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