CRADD

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.[5][6][7]

CRADD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRADD, MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
External IDsOMIM: 603454 MGI: 1336168 HomoloGene: 2821 GeneCards: CRADD
Orthologs
SpeciesHumanMouse
Entrez

8738

12905

Ensembl

ENSG00000169372

ENSMUSG00000045867

UniProt

P78560
Q8IY43

O88843

RefSeq (mRNA)

NM_003805
NM_001320099
NM_001320100
NM_001320101
NM_001330126

NM_009950
NM_001330138
NM_001330141
NM_001330175

RefSeq (protein)

NP_001317067
NP_001317070
NP_001317104
NP_034080

Location (UCSC)Chr 12: 93.68 – 93.89 MbChr 10: 95.01 – 95.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.[7]

Interactions

CRADD has been shown to interact with RIPK1[5][6] and Caspase 2.[5][8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000169372 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000045867 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Duan H, Dixit VM (January 1997). "RAIDD is a new 'death' adaptor molecule" (PDF). Nature. 385 (6611): 86–9. Bibcode:1997Natur.385...86D. doi:10.1038/385086a0. hdl:2027.42/62739. PMID 8985253. S2CID 4317538.
  6. Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES (March 1997). "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP". Cancer Res. 57 (4): 615–9. PMID 9044836.
  7. "Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain".
  8. Tinel A, Tschopp J (May 2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science. 304 (5672): 843–6. Bibcode:2004Sci...304..843T. doi:10.1126/science.1095432. PMID 15073321. S2CID 6583298.
  9. Droin N, Beauchemin M, Solary E, Bertrand R (December 2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade". Cancer Res. 60 (24): 7039–47. PMID 11156409.

Further reading


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