CREG1

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene.[5][6]

CREG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCREG1, CREG, cellular repressor of E1A stimulated genes 1
External IDsOMIM: 618055 MGI: 1344382 HomoloGene: 31199 GeneCards: CREG1
Orthologs
SpeciesHumanMouse
Entrez

8804

433375

Ensembl

ENSG00000143162

ENSMUSG00000040713

UniProt

O75629

O88668

RefSeq (mRNA)

NM_003851

NM_011804

RefSeq (protein)

NP_003842

NP_035934

Location (UCSC)Chr 1: 167.53 – 167.55 MbChr 1: 165.59 – 165.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000143162 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040713 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). "A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F". Mol Cell Biol. 18 (9): 5032–41. doi:10.1128/mcb.18.9.5032. PMC 109088. PMID 9710587.
  6. "Entrez Gene: CREG1 cellular repressor of E1A-stimulated genes 1".

Further reading


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