CRLF3

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[5]

CRLF3
Identifiers
AliasesCRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDsOMIM: 614853 MGI: 1860086 HomoloGene: 9327 GeneCards: CRLF3
Orthologs
SpeciesHumanMouse
Entrez

51379

54394

Ensembl

ENSG00000176390

ENSMUSG00000017561

UniProt

Q8IUI8

Q9Z2L7

RefSeq (mRNA)

NM_015986

NM_001277106
NM_018776

RefSeq (protein)

NP_057070

NP_001264035
NP_061246

Location (UCSC)Chr 17: 30.77 – 30.82 MbChr 11: 79.94 – 79.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called Crlf3tm1a(KOMP)Wtsi[12][13] was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[14][15][16] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[10][17] Twenty six tests were carried out and two significant phenotypes were reported. Homozygous mutant female adults had a significant increase in circulating levels of fructosamine, while mutants of both sexes had decreased platelet cell numbers.[10]

Function

Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.[18]

Origin

Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.[19][20]

References

  1. GRCh38: Ensembl release 89: ENSG00000176390 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017561 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: cytokine receptor-like factor 3".
  6. "Clinical chemistry data for Crlf3". Wellcome Trust Sanger Institute.
  7. "Haematology data for Crlf3". Wellcome Trust Sanger Institute.
  8. "Salmonella infection data for Crlf3". Wellcome Trust Sanger Institute.
  9. "Citrobacter infection data for Crlf3". Wellcome Trust Sanger Institute.
  10. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  11. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  12. "International Knockout Mouse Consortium".
  13. "Mouse Genome Informatics".
  14. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  15. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  16. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  17. van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  18. Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, et al. (2017). "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor". Frontiers in Molecular Neuroscience. 10: 223. doi:10.3389/fnmol.2017.00223. PMC 5509957. PMID 28769759.
  19. Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, et al. (2019). "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience. 12: 251. doi:10.3389/fnmol.2019.00251. PMC 6797617. PMID 31680856.
  20. Liongue C, Ward AC (July 2007). "Evolution of Class I cytokine receptors". BMC Evolutionary Biology. 7 (1): 120. doi:10.1186/1471-2148-7-120. PMC 1963337. PMID 17640376.

Further reading

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