CRYZ

Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.[5]

CRYZ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRYZ, crystallin zeta
External IDsOMIM: 123691 MGI: 88527 HomoloGene: 133907 GeneCards: CRYZ
Orthologs
SpeciesHumanMouse
Entrez

1429

12972

Ensembl

ENSG00000116791

ENSMUSG00000028199

UniProt

Q08257

P47199

RefSeq (mRNA)

NM_001130042
NM_001130043
NM_001134759
NM_001889

NM_009968

RefSeq (protein)

NP_001123514
NP_001123515
NP_001128231
NP_001880

Location (UCSC)Chr 1: 74.71 – 74.73 MbChr 3: 154.6 – 154.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000116791 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028199 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CRYZ crystallin, zeta (quinone reductase)".

Further reading


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