CTNNBIP1

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.[5][6]

CTNNBIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTNNBIP1, ICAT, catenin beta interacting protein 1
External IDsOMIM: 607758 MGI: 1915756 HomoloGene: 10641 GeneCards: CTNNBIP1
Orthologs
SpeciesHumanMouse
Entrez

56998

67087

Ensembl

ENSG00000178585

ENSMUSG00000028988

UniProt

Q9NSA3

Q9JJN6

RefSeq (mRNA)

NM_020248
NM_001012329

NM_001141930
NM_023465

RefSeq (protein)

NP_001012329
NP_064633

NP_001135402
NP_075954

Location (UCSC)Chr 1: 9.85 – 9.91 MbChr 4: 149.6 – 149.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000178585 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028988 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: catenin".
  6. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T (July 2000). "Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein". Genes Dev. 14 (14): 1741–9. doi:10.1101/gad.14.14.1741. PMC 316784. PMID 10898789.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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