CTU2

CTU2
Identifiers
Aliases	CTU2, C16orf84, NCS2, UPF0432, cytosolic thiouridylase subunit 2, MFRG
External IDs	OMIM: 617057 MGI: 1914215 HomoloGene: 79815 GeneCards: CTU2
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	88,715,396 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	123,210,877 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; gastrocnemius muscle; ; left uterine tube; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; left coronary artery; ; popliteal artery; ; anterior pituitary; ; right coronary artery;
	Top expressed in
	Paneth cell; ; fossa; ; medullary collecting duct; ; condyle; ; trigeminal ganglion; ; renal corpuscle; ; internal carotid artery; ; hair follicle; ; external carotid artery; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA binding; protein binding; sulfurtransferase activity; nucleotidyltransferase activity;
Cellular component	cytoplasm; cytosol; protein-containing complex;
Biological process	tRNA wobble uridine modification; tRNA thio-modification; tRNA processing; tRNA wobble position uridine thiolation; protein urmylation; tRNA modification;
	Sources:Amigo / QuickGO
Orthologs
	348180
	66965
	ENSG00000174177
	ENSMUSG00000049482
	Q2VPK5
	Q3U308
	NM_001012759; NM_001012762; NM_001318507; NM_001318513
	NM_153775
	NP_001012777; NP_001012780; NP_001305436; NP_001305442
	NP_722470
	Wikidata
View/Edit Human	View/Edit Mouse

CTU2 (formerly known as C16orf84) is a human gene located on chromosome 16.[5] The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification.[6]

References

GRCh38: Ensembl release 89: ENSG00000174177 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049482 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: C16orf84". 24 December 2015.
"NCBI protein: cytoplasmic tRNA 2-thiolation protein 2 isoform 1".

External links

Human CTU2 genome location and CTU2 gene details page in the UCSC Genome Browser.

Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL (November 2008). "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18255–60. Bibcode:2008PNAS..10518255S. doi:10.1073/pnas.0808756105. PMC 2584574. PMID 19017811.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (August 2008). "A quantitative atlas of mitotic phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 105 (31): 10762–7. Bibcode:2008PNAS..10510762D. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174177 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049482 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C16orf84". 24 December 2015.

[PubMed-6] "NCBI protein: cytoplasmic tRNA 2-thiolation protein 2 isoform 1".

CTU2

References

External links

Further reading