CYB5R1

NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene.[5][6][7]

CYB5R1
Identifiers
AliasesCYB5R1, B5R.1, B5R1, B5R2, NQO3A2, humb5R2, cytochrome b5 reductase 1
External IDsOMIM: 608341 MGI: 1919267 HomoloGene: 96059 GeneCards: CYB5R1
Orthologs
SpeciesHumanMouse
Entrez

51706

72017

Ensembl

ENSG00000159348

ENSMUSG00000026456

UniProt

Q9UHQ9

Q9DB73

RefSeq (mRNA)

NM_016243

NM_028057
NM_001355133

RefSeq (protein)

NP_057327

NP_082333
NP_001342062

Location (UCSC)Chr 1: 202.96 – 202.97 MbChr 1: 134.33 – 134.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure

The CYB5R1 gene is located on the 1st chromosome, with its specific location being 1q32.1. The gene contains 9 exons.[7] CYB5R1 encodes a 34.1 kDa protein that is composed of 305 amino acids; 56 peptides have been observed through mass spectrometry data.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000159348 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026456 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  6. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Dec 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
  7. "Entrez Gene: CYB5R1 cytochrome b5 reductase 1".
  8. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  9. "NADH-cytochrome b5 reductase 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

Further reading


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