CYREN (protein)

CYREN
Identifiers
Aliases	CYREN, MRI, chromosome 7 open reading frame 49, MRI-2, C7orf49, cell cycle regulator of NHEJ
External IDs	OMIM: 616980 MGI: 1925662 HomoloGene: 49745 GeneCards: CYREN
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	135,170,795 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	34,854,995 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right lung; ; monocyte; ; right lobe of liver; ; upper lobe of left lung; ; gastric mucosa; ; tibial nerve; ; spleen; ; gallbladder; ; islet of Langerhans;
	Top expressed in
	bone marrow; ; yolk sac; ; proximal tubule; ; quadriceps femoris muscle; ; muscle tissue; ; liver; ; mirror; ; placenta; ; skeletal muscle tissue; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; nucleus;
Biological process	double-strand break repair via nonhomologous end joining; DNA repair; cellular response to DNA damage stimulus; negative regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
	78996
	78412
	ENSG00000122783
	ENSMUSG00000046806
	Q9BWK5
	Q8BHZ5
NM_024033; NM_001243749; NM_001243751; NM_001243752; NM_001243753;
	NM_001243754; NM_001243755; NM_001305629; NM_001305630; NM_001363329; NM_001363330
	NM_001135611; NM_199145; NM_001347101
NP_001230678; NP_001230680; NP_001230681; NP_001230682; NP_001230683;
	NP_001230684; NP_001292558; NP_001292559; NP_076938; NP_001350258; NP_001350259
	NP_001129083; NP_001334030; NP_954596
	Wikidata
View/Edit Human	View/Edit Mouse

Cell cycle regulator of non-homologous end joining is a protein that in humans is encoded by the CYREN gene.

It prevents classical non-homologous end joining, a method of repair of double-stranded DNA breaks.[5] This protein is therefore important in regulating DNA repair.

When alternatively spliced, is predicted to produce three different micropeptides.[6]

MRI-1 was previously found to be a modulator of retrovirus infection.[6]
MRI-2 may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway.[6]
MRI-3

References

GRCh38: Ensembl release 89: ENSG00000122783 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000046806 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J (September 2017). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. Bibcode:2017Natur.549..548A. doi:10.1038/nature24023. PMC 5624508. PMID 28959974.
Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A (April 2014). "A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining". The Journal of Biological Chemistry. 289 (16): 10950–7. doi:10.1074/jbc.c113.533968. PMC 4036235. PMID 24610814.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122783 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046806 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J (September 2017). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. Bibcode:2017Natur.549..548A. doi:10.1038/nature24023. PMC 5624508. PMID 28959974.

[Slavoff_2014-6] Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A (April 2014). "A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining". The Journal of Biological Chemistry. 289 (16): 10950–7. doi:10.1074/jbc.c113.533968. PMC 4036235. PMID 24610814.