Calamine

Calamine, also known as calamine lotion, is a medication made from powdered calamine mineral that is used to treat mild itchiness.[2][3] Conditions treated include sunburn, insect bites, poison ivy, poison oak, and other mild skin conditions.[4][5] It may also help dry out skin irritation.[1] It is applied on the skin as a cream or lotion.[2]

Not to be confused with Chamomile.
This article is about the medication. For other uses, see Calamine (disambiguation).
Calamine
A puddle of a thin pink lotion, next to a pink plastic bottle
Combination of
zinc oxideastringent
ferric oxideantipruritic
Clinical data
PronunciationKAL-ə-mine[1]
Other namesCalamine lotion
License data
Routes of
administration		Topical
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEMBL
Chemical and physical data
3D model (JSmol)
  • [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2]
  • InChI=1S/2Fe.4O.Zn/q2*+3;4*-2;+2
  • Key:CPYIZQLXMGRKSW-UHFFFAOYSA-N
Look up calamine in Wiktionary, the free dictionary.

Side effects may include skin irritation.[4] It is considered to be safe in pregnancy.[4] Calamine is a combination of zinc oxide and 0.5% ferric oxide (Fe2O3).[6] The lotion is produced with additional ingredients such as phenol and calcium hydroxide.[6][7]

The use of calamine lotion dates back as far as 1500 BC.[8] It is on the World Health Organization's List of Essential Medicines.[9] Calamine is available over-the-counter as a generic medication.[5]

Medical uses

Calamine is used to treat itchiness.[2] This includes sunburn, insect bite, or other mild skin conditions.[4][5]

Effectiveness

The FDA recommends applying some topical over-the-counter skin products, such as calamine, to absorb the weeping of the skin caused by poisonous plants such as poison ivy, poison oak, and poison sumac. For relieving the pain or itching caused by these plants, the FDA document recommends a cold water compress and topical corticosteroids.[10]

References
  1. "Calamine (topical) medical facts from Drugs.com". www.drugs.com. Archived from the original on 2017-11-07.
  2. British National Formulary: BNF 69 (69 ed.). British Medical Association. 2015. p. 801. ISBN 9780857111562.
  3. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 303. hdl:10665/44053. ISBN 9789241547659.
  4. "Aqueous Calamine Cream BP - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 18 November 2016. Archived from the original on 30 December 2016. Retrieved 29 December 2016.
  5. Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 191. ISBN 9781284057560.
  6. Braun-Falco O, Plewig G, Wolff HH, Burgdorf W (2012). "Topical Therapy". Dermatology (2nd ed.). Springer Science & Business Media. p. 1724. ISBN 9783642979316. Archived from the original on 2016-12-29.
  7. Ma JK, Hadzija B (2012). "Rheology in Pharmacy". Basic Physical Pharmacy. Jones & Bartlett Publishers. p. 327. ISBN 9780763757342. Archived from the original on 2016-12-30.
  8. Darnton-Hill I, Ahmed F, Samman S (2016). "The impact of micronutrients on inflammation and health in low-and middle-income countries.". In Bendich A, Deckelbaum RJ (eds.). Preventive Nutrition: The Comprehensive Guide for Health Professionals (5th ed.). Springer. pp. 597-644 (608). ISBN 9783319224312. Archived from the original on 2016-12-30.
  9. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  10. "Outsmarting Poison Ivy and Other Poisonous Plants". U.S. Food and Drug Administration: Consumer Updates. 9 June 2021 [Originally posted c. June 2009, since updated but advice unchanged]. Archived from the original on 5 June 2009.
  • "Calamine". Drug Information Portal. U.S. National Library of Medicine.
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