Calfactant

Calfactant
Clinical data
Trade names	Infasurf
Pregnancy; category	N;
ATC code	none;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	183325-78-2 ;
ChemSpider	none;
UNII	Q4K217VGA9;
ChEMBL	ChEMBL1201447 ;
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Calfactant, also known as Infasurf,[1] is an intratracheal suspension derived from the natural surfactant in calf lungs. It is used in premature infants with lung surfactant deficiency that causes infant respiratory distress syndrome (IRDS).[2]

Mechanism of action

Lung surfactant is essential for effective ventilation as it modifies alveolar surface tension.[3] IRDS is caused by a lung surfactant deficiency. Calfactant serves as a substitute for the natural surfactant.[2]

References

"Infasurf". Archived from the original on 2011-12-09. Retrieved 2011-12-16.
Drugs.com: "Calfactant". Drugs.com.
Schurch S, Lee M, Gehr P (1992). "Pulmonary surfactant: Surface properties and function of alveolar and airway surfactant". Pure and Applied Chemistry. 64 (11): 1745–1750. doi:10.1351/pac199264111745. S2CID 97007574.

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[1] "Infasurf". Archived from the original on 2011-12-09. Retrieved 2011-12-16.

[Drug.com-2] Drugs.com: "Calfactant". Drugs.com.

[3] Schurch S, Lee M, Gehr P (1992). "Pulmonary surfactant: Surface properties and function of alveolar and airway surfactant". Pure and Applied Chemistry. 64 (11): 1745–1750. doi:10.1351/pac199264111745. S2CID 97007574.