Calmodulin 1

Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene.[3]

CALM1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCALM1, CALML2, CAMI, CPVT4, DD132, PHKD, caM, LQT14, Calmodulin 1, calmodulin 1 (phosphorylase kinase, delta), CAMC, CAMB, CAMIII, CAM3, CAM2
External IDsOMIM: 114180 HomoloGene: 134804 GeneCards: CALM1
Orthologs
SpeciesHumanMouse
Entrez

801

n/a

Ensembl

ENSG00000198668

n/a

UniProt

P0DP23
P0DP24

n/a

RefSeq (mRNA)

NM_001166106
NM_006888
NM_001363669
NM_001363670

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 14: 90.4 – 90.41 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Calmodulin 1 is the archetype of the family of calcium-modulated (calmodulin) proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding EF hand motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[4]

Interactions

Calmodulin 1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000198668 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Wawrzynczak EJ, Perham RN (August 1984). "Isolation and nucleotide sequence of a cDNA encoding human calmodulin". Biochem. Int. 9 (2): 177–85. PMID 6385987.
  4. "Entrez Gene: CALM1 calmodulin 1 (phosphorylase kinase, delta)".
  5. Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  6. Cifuentes E, Mataraza JM, Yoshida BA, Menon M, Sacks DB, Barrack ER, Reddy GP (Jan 2004). "Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 464–9. Bibcode:2004PNAS..101..464C. doi:10.1073/pnas.0307161101. PMC 327170. PMID 14695896.
  7. Li Z, Sacks DB (Feb 2003). "Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1". J. Biol. Chem. 278 (6): 4347–52. doi:10.1074/jbc.M208579200. PMID 12446675.
  8. Briggs MW, Li Z, Sacks DB (Mar 2002). "IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin". J. Biol. Chem. 277 (9): 7453–65. doi:10.1074/jbc.M104315200. PMID 11734550.
  9. Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N (May 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. PMID 12051765.
  10. Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M (Jun 2003). "Structural determinant of TRPV1 desensitization interacts with calmodulin". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 8002–6. Bibcode:2003PNAS..100.8002N. doi:10.1073/pnas.1337252100. PMC 164702. PMID 12808128.

Further reading

  • UniProt.[1] Calm1 Human Gene


  1. "CALM1 Gene", Definitions, Qeios, 2020-02-07, retrieved 2023-10-16
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