Capping protein (actin filament) muscle Z-line, alpha 1

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.[5][6][7]

CAPZA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1, capping actin protein of muscle Z-line subunit alpha 1
External IDsOMIM: 601580 MGI: 106227 HomoloGene: 24376 GeneCards: CAPZA1
Orthologs
SpeciesHumanMouse
Entrez

829

12340

Ensembl

ENSG00000116489

ENSMUSG00000070372

UniProt

P52907

P47753

RefSeq (mRNA)

NM_006135

NM_009797
NM_001355044

RefSeq (protein)

NP_006126

NP_033927
NP_001341973

Location (UCSC)Chr 1: 112.62 – 112.67 MbChr 3: 104.73 – 104.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.[7] This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.

References

  1. GRCh38: Ensembl release 89: ENSG00000116489 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070372 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Barron-Casella EA, Torres MA, Scherer SW, Heng HH, Tsui LC, Casella JF (Oct 1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families". J Biol Chem. 270 (37): 21472–9. doi:10.1074/jbc.270.37.21472. PMID 7665558.
  6. Hart MC, Korshunova YO, Cooper JA (Apr 1997). "Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes". Genomics. 39 (3): 264–70. doi:10.1006/geno.1996.4506. PMID 9119363.
  7. "Entrez Gene: CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1".

Further reading


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