Carboxylesterase 2

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.[5][6][7] It is a member of the alpha/beta fold hydrolase family.[8]

CES2
Identifiers
AliasesCES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
External IDsOMIM: 605278 MGI: 3648740 HomoloGene: 128645 GeneCards: CES2
Orthologs
SpeciesHumanMouse
Entrez

8824

436059

Ensembl

ENSG00000172831

ENSMUSG00000091813

UniProt

O00748

F6Z9B9

RefSeq (mRNA)

NM_001272045

RefSeq (protein)

NP_001258974

Location (UCSC)Chr 16: 66.93 – 66.95 MbChr 8: 105.73 – 105.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Irinotecan Pathway edit
  1. The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

References

  1. GRCh38: Ensembl release 89: ENSG00000172831 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000091813 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (June 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". The Journal of Biological Chemistry. 272 (23): 14769–14775. doi:10.1074/jbc.272.23.14769. PMID 9169443.
  6. Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (April 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochemical and Biophysical Research Communications. 233 (1): 117–120. doi:10.1006/bbrc.1997.6413. PMID 9144407.
  7. "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
  8. Imai T (June 2006). "Human carboxylesterase isozymes: catalytic properties and rational drug design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

Further reading


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