Carnosol

Carnosol is a phenolic diterpene found in the herbs rosemary (Rosmarinus officinalis)[1] and Mountain desert sage (Salvia pachyphylla).[2]

Carnosol
Chemical structure of carnosol
Names
IUPAC name
11,12-Dihydroxy-7β,20-epoxyabieta-8,11,13-trien-20-one
Systematic IUPAC name
(4aR,9S,10aS)-5,6-Dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydro-2H-9,4a-(epoxymethano)phenanthren-12-one
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
    Key: XUSYGBPHQBWGAD-PJSUUKDQSA-N
  • InChI=1/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
    Key: XUSYGBPHQBWGAD-PJSUUKDQBN
  • CC(C)C1=CC2=C(C(=C1O)O)[C@@]34CCCC([C@@H]3C[C@@H]2OC4=O)(C)C
Properties
C20H26O4
Molar mass 330.424 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

It has been studied in-vitro for anti-cancer effects in various cancer cell types.[3]

carnosol have defensive consequences against sepsis-induced myocardial and other inflammatory diseases involving the NF-κB signaling pathway, including myocarditis and inflammatory cardiomyopathy. [4]

See also

References
  1. Ai-Hsiang Lo; Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin (2002). "Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages". Carcinogenesis. 23 (6): 983–991. doi:10.1093/carcin/23.6.983. PMID 12082020.
  2. Ivan C. Guerrero; Lucia S. Andres; Leticia G. Leon; Ruben P. Machin; Jose M. Padron; Javier G. Luis; Jose Delgadillo (2006). "Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines". J. Nat. Prod. 69 (12): 1803–1805. doi:10.1021/np060279i. PMID 17190465.
  3. Johnson JJ (June 2011). "Carnosol: a promising anti-cancer and anti-inflammatory agent". Cancer Lett. 305 (1): 1–7. doi:10.1016/j.canlet.2011.02.005. PMC 3070765. PMID 21382660.
  4. Rahimi VB (May 2022). "Carnosol Attenuates LPS-Induced Inflammation of Cardiomyoblasts by Inhibiting NF-κB: A Mechanistic in Vitro and in Silico Study". Evidence-Based Complementary and Alternative Medicine. 2022. doi:10.1155/2022/7969422. PMC 9095375. PMID 35571740.


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