Cartilage-derived angiogenesis inhibitor

A cartilage-derived angiogenesis inhibitor is an angiogenesis inhibitor produced from cartilage. Examples include the peptide troponin I[1] and chondromodulin I.[2] The antiangiogenic effect may be an inhibition of basement membrane degradation.

These inhibitory agents prevent 'vascular invasion',[3] which is the proliferation of tumor cells in the blood or lymph vessels. They are usually highly expressed in cartilage and within chondrocytes. Their genetic transcription increases upon the expansion of cartilaginous regions.[3]

Recent studies on Troponin I[4] hypothesize that this protein performs its anti-proliferation effect on endothelial cells via interactions with a bFGF receptor.[4] Neighboring studies on other anti-angiogenic factors are evolving, however, the general mechanism of action is still unknown today.

References
  1. Kern BE, Balcom JH, Antoniu BA, Warshaw AL, Fernández-del Castillo C (2003). "Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer". J. Gastrointest. Surg. 7 (8): 961–8, discussion 969. doi:10.1016/j.gassur.2003.08.003. PMID 14675705. S2CID 35612244.
  2. Setoguchi K, Misaki Y, Kawahata K, et al. (March 2004). "Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis". Arthritis Rheum. 50 (3): 828–39. doi:10.1002/art.20193. PMID 15022325.
  3. Shukunami, C.; Hiraki, Y. (2001). "Role of cartilage-derived anti-angionec factor, chondromodulin-I, during endochondral bone formation". Osteoarthritis and Cartilage. 9 (Suppl 1): S91–S101. doi:10.1053/joca.2001.0450. PMID 11680695.
  4. Feldman, Laurie; Rouleau, Cecile (2002). "Troponin I Inhibits Capillary Endothelial Cell Proliferation by Interaction with the Cell's bFGF Receptor". Microvascular Research. 63 (1): 41–49. doi:10.1006/mvre.2001.2364. PMID 11749071. Retrieved 4 December 2020.


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