Lysyl endopeptidase

Lysyl endopeptidase (EC 3.4.21.50, Achromobacter proteinase I, Achromobacter lyticus alkaline proteinase I, protease I, achromopeptidase, lysyl bond specific proteinase, and caseinase) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Preferential cleavage: Lys-, including -Lys-Pro-
Lysyl endopeptidase (R)
Identifiers
EC no.3.4.21.50
CAS no.123175-82-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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NCBIproteins

This enzyme is isolated from Lysobacter enzymogenes.

It is produced by the human body and by Achromobacter lyticus[7] that can help break down the protein casein in milk into smaller peptides and amino acids.[8]

References
  1. Masaki T, Tanabe M, Nakamura K, Soejima M (July 1981). "Studies on a new proteolytic enzyme from A chromobacter lyticus M497-1. I. Purification and some enzymatic properties". Biochimica et Biophysica Acta. 660 (1): 44–50. doi:10.1016/0005-2744(81)90106-6. PMID 6791693.
  2. Masaki T, Fujihashi T, Nakamura K, Soejima M (July 1981). "Studies on a new proteolytic enzyme from Achromobacter lyticus M497-1. II. specificity and inhibition studies of Achromobacter protease I". Biochimica et Biophysica Acta. 660 (1): 51–5. doi:10.1016/0005-2744(81)90107-8. PMID 6168293.
  3. Jekel PA, Weijer WJ, Beintema JJ (October 1983). "Use of endoproteinase Lys-C from Lysobacter enzymogenes in protein sequence analysis". Analytical Biochemistry. 134 (2): 347–54. doi:10.1016/0003-2697(83)90308-1. PMID 6359954.
  4. Elliott BW, Cohen C (August 1986). "Isolation and characterization of a lysine-specific protease from Pseudomonas aeruginosa". The Journal of Biological Chemistry. 261 (24): 11259–65. doi:10.1016/S0021-9258(18)67377-6. PMID 3090046.
  5. Ohara T, Makino K, Shinagawa H, Nakata A, Norioka S, Sakiyama F (December 1989). "Cloning, nucleotide sequence, and expression of Achromobacter protease I gene". The Journal of Biological Chemistry. 264 (34): 20625–31. doi:10.1016/S0021-9258(19)47109-3. PMID 2684982.
  6. Tsunasawa S, Masaki T, Hirose M, Soejima M, Sakiyama F (March 1989). "The primary structure and structural characteristics of Achromobacter lyticus protease I, a lysine-specific serine protease". The Journal of Biological Chemistry. 264 (7): 3832–9. doi:10.1016/S0021-9258(19)84926-8. PMID 2492988.
  7. "BRENDA - Information on EC 3.4.21.50 - lysyl endopeptidase". www.brenda-enzymes.org. Retrieved 2018-05-28.
  8. "Caseinase Definition and Examples - Biology Online Dictionary". 7 October 2019.
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