Cathepsin L2

Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in humans by the CTSV gene.[5][6][7][8]

CTSV
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSV, cathepsin V, CATL2, CTSL2, CTSU
External IDsOMIM: 603308 MGI: 88564 HomoloGene: 76699 GeneCards: CTSV
Orthologs
SpeciesHumanMouse
Entrez

1515

13039

Ensembl

ENSG00000136943

ENSMUSG00000021477

UniProt

O60911

P06797

RefSeq (mRNA)

NM_001333
NM_001201575

NM_009984

RefSeq (protein)

NP_001188504
NP_001324

NP_034114

Location (UCSC)Chr 9: 97.03 – 97.16 MbChr 13: 64.51 – 64.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein is a human cysteine cathepsin, a lysosomal cysteine protease with endopeptidase activity.

The protein is a member of the papain-like protease family (MEROPS family C1), a lysosomal cysteine protease with endopeptidase activity. It may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Clinical significance

Cathepsin L2 may play a role in the pathogenesis of keratoconus.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CTSL2 cathepsin L2".
  6. Brömme D, Li Z, Barnes M, Mehler E (February 1999). "Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization". Biochemistry. 38 (8): 2377–85. doi:10.1021/bi982175f. PMID 10029531.
  7. Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K (September 1998). "Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium". Investigative Ophthalmology & Visual Science. 39 (10): 1789–96. PMID 9727401.
  8. Santamaría I, Velasco G, Cazorla M, Fueyo A, Campo E, López-Otín C (April 1998). "Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas". Cancer Research. 58 (8): 1624–30. PMID 9563472.
  9. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ (2005). "Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder". Invest. Ophthalmol. Vis. Sci. 46 (3): 823–832. doi:10.1167/iovs.04-0549. PMID 15728537.

Further reading

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