SERPINA9

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.[5] Serpin A9 is a member of the serpin family of serine protease inhibitors.

SERPINA9
Identifiers
AliasesSERPINA9, GCET1, SERPINA11, SERPINA11b, serpin family A member 9
External IDsOMIM: 615677 MGI: 1919157 HomoloGene: 23633 GeneCards: SERPINA9
Orthologs
SpeciesHumanMouse
Entrez

327657

71907

Ensembl

ENSG00000170054

ENSMUSG00000058260

UniProt

Q86WD7

Q9D7D2

RefSeq (mRNA)

NM_001042518
NM_001284275
NM_001284276
NM_175739

NM_027997
NM_001361910
NM_001361912

RefSeq (protein)

NP_001035983
NP_001271204
NP_001271205
NP_783866

NP_082273
NP_001348839
NP_001348841

Location (UCSC)Chr 14: 94.46 – 94.48 MbChr 12: 103.96 – 103.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[6][7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000170054 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000058260 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SERPINA9".
  6. Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896.
  7. Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
  8. Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480.

Further reading


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