Cerein

Cereins are a group of bacteriocins produced by various strains of the bacterium Bacillus cereus. Although all cereins are by definition produced by B. cereus, it is possible that they are chemically quite different from one another. Cereins have been found to be active against other strains of B. cereus,[1] as well as a broad range of other gram-positive bacteria. Like other bacteriocins, cereins are generally named after the strain in which their production was first discovered. Named cereins include cerein 7,[2] cerein 7B,[3] cerein 8A,[4] and cerein MRX1.[5]

Clinical Research

It has been studies that a type of cerein 8A is very effective in inhibiting the effects of the pathogenic bacteria Salmonella enterica subsp. enterica that causes diarrhea, stomach aches, and fever.[6][7] In clinical research, it was discovered that cerein 8A in combination with combination with sodium lactate killed Salmonella enterica in a dose-dependent fashion.[8] Cerein 8A was also found to inhibit growth of Listeria monocytogenes, a pathogenic bacteria commonly found in dairy products such as milk.[9][10]

References
  1. Naclerio, G; Ricca, E; Sacco, M; De Felice, M (December 1993). "Antimicrobial activity of a newly identified bacteriocin of Bacillus cereus". Appl Environ Microbiol. 59 (12): 4313–6. doi:10.1128/aem.59.12.4313-4316.1993. PMC 195902. PMID 8285719.
  2. Oscátriz, Juan Carlos; Lasa, Iñigo; Pisabarro, Antonio (19 September 1999). "Detection and characterization of cerein 7, a new bacteriocin produced by Bacillus cereus with a broad spectrum of activity". FEMS Microbiol. Lett. 178 (2): 337–341. doi:10.1016/s0378-1097(99)00370-5. PMID 10499284.
  3. Oscátriz, JC; Cintas, L; Holo, H; Lasa, I; Nes, IF; Pisabarro, AG (January 2006). "Purification and sequencing of cerein 7B, a novel bacteriocin produced by Bacillus cereus Bc7". FEMS Microbiol. Lett. 254 (1): 108–15. doi:10.1111/j.1574-6968.2005.00009.x. PMID 16451187.
  4. Bizani, B; Brandelli, A (September 2002). "Characterization of a bacteriocin produced by a newly isolated Bacillus sp. Strain 8 A". Journal of Applied Microbiology. 93 (3): 512–519. doi:10.1046/j.1365-2672.2002.01720.x. PMID 12174052. S2CID 32222260.
  5. Sebei, S; Zendo, T; Boudabous, A; Nakayama, J; Sonomoto, K (November 2007). "Characterization, N-terminal sequencing and classification of cerein MRX1, a novel bacteriocin purified from a newly isolated bacterium: Bacillus cereus MRX1". J Appl Microbiol. 103 (5): 1621–31. doi:10.1111/j.1365-2672.2007.03395.x. PMID 17953573.
  6. "Symptoms | Salmonella | CDC". www.cdc.gov. 2019-12-12. Retrieved 2021-05-02.
  7. "CDC - Signs & Symptoms - Salmonella Enteritidis Infections Linked to Ground Beef - Salmonella". www.cdc.gov. 2019-01-31. Retrieved 2021-05-02.
  8. Lappe, Rosiele; Motta, Amanda S.; Sant'Anna, Voltaire; Brandelli, Adriano (15 November 2009). "Sign in | Hunter College Libraries". International Journal of Food Microbiology. 135 (3): 312–316. doi:10.1016/j.ijfoodmicro.2009.09.003. PMID 19775768. Retrieved 2021-05-02.
  9. "Listeria (Listeriosis) | Listeria | CDC". www.cdc.gov. 2021-02-24. Retrieved 2021-05-02.
  10. Bizani, Delmar; Morrissy, Juliana A. C.; Dominguez, Ana P. M.; Brandelli, Adriano (31 January 2008). "Sign in | Hunter College Libraries". International Journal of Food Microbiology. 121 (2): 229–233. doi:10.1016/j.ijfoodmicro.2007.11.016. PMID 18068253. Retrieved 2021-05-02.


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