Chantal Stern

Chantal Stern is a neuroscientist who uses techniques including functional magnetic resonance imaging (fMRI) to study the brain mechanisms of memory function. She is the Director of the Brain, Behavior and Cognition program and a professor of Psychological and Brain Sciences at Boston University. After completing a degree at McGill University, she performed her doctoral research at Oxford University with Richard Passingham.

Stern earned a DPhil in Experimental Psychology from Oxford University and a BA in psychology from McGill University.

Imaging of hippocampal activation during encoding

Stern published the earliest functional magnetic resonance imaging study showing robust increases in blood flow to the hippocampus during memory encoding.[1] Prior to this study, imaging studies did not observe robust changes in hippocampus during verbal memory tasks, but this study demonstrated clear increases in blood flow during encoding of complex novel visual scenes. This result was subsequently replicated in numerous studies demonstrating activity in the hippocampus and associated parahippocampal cortical regions during encoding of new information, including work showing that the magnitude of hippocampal activity during encoding of stimuli correlates with recognition of stimuli in subsequent memory tests.[2]

Medial temporal lobe activity during working memory for novel stimuli

Stern demonstrated that holding novel visual scenes in working memory involves activation of medial temporal lobe structures.[3] This activation of medial temporal lobe for novel visual scenes contrasted with activation for familiar visual scenes that primarily appeared in the prefrontal cortex and parietal cortex, which were the focus of most previous fMRI studies of working memory function for familiar stimuli.[4] Subsequent data supports this finding, including work showing impairments of working memory for novel stimuli caused by medial temporal lobe damage.[5] In subsequent work, Stern linked this medial temporal lobe activity to mechanisms of persistent spiking shown in individual neurons.[6]

Hyperactivity in the hippocampus in presymptomatic familial Alzheimer's disease

Research in the Stern laboratory has addressed a range of clinical disorders, including HIV dementia, Parkinson's dementia and Alzheimer's disease. In research with Dr. Yakeel Quiroz, Stern showed higher fMRI signal (hyperactivity) in the hippocampal formation in young subjects with a mutation of the presenilin1 gene that results in familial Alzheimer's disease.[7] This finding in young subjects before they showed other symptoms of Alzheimer's disease provides a dramatic extension beyond earlier studies showing hippocampal hyperactivation in elderly subjects with mild cognitive impairment.

References
  1. Stern CE, Corkin S, González RG, Guimaraes AR, Baker JR, Jennings PJ, Carr CA, Sugiura RM, Vedantham V, Rosen BR. (1996) The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci U S A. 93(16):8660-5.
  2. Kirchhoff BA, Wagner AD, Maril A, Stern CE. (2000) Prefrontal-temporal circuitry for episodic encoding and subsequent memory. J. Neurosci. 20(16):6173-80.
  3. Stern CE, Sherman SJ, Kirchhoff BA, Hasselmo ME. (2001) Medial temporal and prefrontal contributions to working memory tasks with novel and familiar stimuli. Hippocampus. 11(4):337-46.
  4. Braver TS, Cohen JD, Nystrom LE, Jonides J, Smith EE, Noll DC. (1997) A parametric study of prefrontal cortex involvement in human working memory. Neuroimage 5(1):49-62.
  5. Olson IR, Page K, Moore KS, Chatterjee A, Verfaellie M. (2006) Working memory for conjunctions relies on the medial temporal lobe. J Neurosci. 26(17):4596-601.
  6. Schon K, Hasselmo ME, Lopresti ML, Tricarico MD, Stern CE. (2004) Persistence of parahippocampal representation in the absence of stimulus input enhances long-term encoding: a functional magnetic resonance imaging study of subsequent memory after a delayed match-to-sample task. J Neurosci. 24(49):11088-97.
  7. Quiroz YT, Budson AE, Celone K, Ruiz A, Newmark R, Castrillón G, Lopera F, Stern CE. (2010) Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease. Ann Neurol. 68(6):865-75.
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