Choline/ethanolamine kinase family

In molecular biology, the choline/ethanolamine kinase family includes choline kinase(EC 2.7.1.32) and ethanolamine kinase (EC 2.7.1.82).

Choline_kinase
crystal structure of choline kinase
Identifiers
SymbolCholine_kinase
PfamPF01633
Pfam clanCL0016
InterProIPR002573
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment.[1] The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway.[2][3] There are two putative choline/ethanolamine kinases (C/EKs) in the Trypanosoma brucei genome.

Ethanolamine kinase has no choline kinase activity [1] and its activity is inhibited by ADP.[3] Inositol supplementation represses ethanolamine kinase, decreasing the incorporation of ethanolamine into the CDP-ethanolamine pathway and into phosphatidylethanolamine and phosphatidylcholine.[4]

References
  1. Gibellini F, Hunter WN, Smith TK (October 2008). "Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases". Biochem. J. 415 (1): 135–44. doi:10.1042/BJ20080435. PMC 2552378. PMID 18489261.
  2. Tian Y, Jackson P, Gunter C, Wang J, Rock CO, Jackowski S (September 2006). "Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2". J. Biol. Chem. 281 (38): 28438–49. doi:10.1074/jbc.M605861200. PMID 16861741.
  3. Kim KH, Voelker DR, Flocco MT, Carman GM (March 1998). "Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae". J. Biol. Chem. 273 (12): 6844–52. doi:10.1074/jbc.273.12.6844. PMID 9506987.
  4. Kersting MC, Choi HS, Carman GM (August 2004). "Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline". J. Biol. Chem. 279 (34): 35353–9. doi:10.1074/jbc.M405704200. PMID 15201274.
This article incorporates text from the public domain Pfam and InterPro: IPR002573
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