Chondroitin-glucuronate 5-epimerase

In enzymology, a chondroitin-glucuronate 5-epimerase (EC 5.1.3.19) is an enzyme that catalyzes the chemical reaction

chondroitin D-glucuronate dermatan L-iduronate
chondroitin-glucuronate 5-epimerase
Identifiers
EC no.5.1.3.19
CAS no.86417-91-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, chondroitin D-glucuronate, and one product, dermatan L-iduronate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is chondroitin-D-glucuronate 5-epimerase. Other names in common use include polyglucuronate 5-epimerase, dermatan-sulfate 5-epimerase, urunosyl C-5 epimerase, and chondroitin D-glucuronosyl 5-epimerase. This enzyme participates in chondroitin sulfate biosynthesis.

References

    • Malmstrom A, Aberg L (1982). "Biosynthesis of dermatan sulphate. Assay and properties of the uronosyl C-5 epimerase". Biochem. J. 201 (3): 489–93. doi:10.1042/bj2010489. PMC 1163673. PMID 7092807.


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