Chymase

Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8). Recently, Derakhshan et al. reported that a specific mast cell population expressed transcripts for Mcpt8.[1] They show broad peptidolytic activity and are involved in a variety of functions. For example, chymases are released by connective tissue-type mast cells upon challenge with parasites and parasite antigens promoting an inflammatory response, and chymase mcp1 and mcp2 are used for marker for mast cell degranulation in parasite infection such as Nematode,[2] Trichuris muris[3][4] Chymases are also known to convert angiotensin I to angiotensin II and thus play a role in hypertension and atherosclerosis.[5]

chymase 1, mast cell
Chymase with PMSF bound PDB: 1KLT
Identifiers
SymbolCMA1
NCBI gene1215
HGNC2097
OMIM118938
RefSeqNM_001836
UniProtP23946
Other data
EC number3.4.21.39
LocusChr. 14 q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Because of its role in inflammation it has been investigated as a target in the treatment of asthma.[6]

References
  1. Derakhshan, Tahereh; Samuchiwal, Sachin K.; Hallen, Nils; Bankova, Lora G.; Boyce, Joshua A.; Barrett, Nora A.; Austen, K. Frank; Dwyer, Daniel F. (2021-01-04). "Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation". Journal of Experimental Medicine. 218 (1): e20200321. doi:10.1084/jem.20200321. ISSN 0022-1007. PMC 7953627. PMID 32946563.
  2. McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR, Grencis RK (June 2003). "Mast cells disrupt epithelial barrier function during enteric nematode infection". Proceedings of the National Academy of Sciences of the United States of America. 100 (13): 7761–6. Bibcode:2003PNAS..100.7761M. doi:10.1073/pnas.1231488100. PMC 164661. PMID 12796512.
  3. Betts CJ, Else KJ (January 1999). "Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris". Parasite Immunology. 21 (1): 45–52. doi:10.1046/j.1365-3024.1999.00200.x. PMID 10081771. S2CID 31343469.
  4. Blackwell NM, Else KJ (June 2001). "B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris". Infection and Immunity. 69 (6): 3860–8. doi:10.1128/IAI.69.6.3860-3868.2001. PMC 98409. PMID 11349052.
  5. Caughey GH (June 2007). "Mast cell tryptases and chymases in inflammation and host defense". Immunological Reviews. 217: 141–54. doi:10.1111/j.1600-065X.2007.00509.x. PMC 2275918. PMID 17498057.
  6. de Garavilla L, Greco MN, Sukumar N, Chen ZW, Pineda AO, Mathews FS, et al. (May 2005). "A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo". The Journal of Biological Chemistry. 280 (18): 18001–7. doi:10.1074/jbc.M501302200. PMID 15741158.


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