Clemens van Blitterswijk

Clemens A. van Blitterswijk (1957, The Hague) is a Dutch tissue engineer who contributed to the use of biomaterials to heal bone injuries, especially using osteoinductive ceramics.[1][2] In collaboration with Jan de Boer and others, he has contributed to screening microtextures to study cell-biomaterial interactions, an approach termed materiomics.

Clemens van Blitterswijk
Clemens van Blitterswijk
Born1957 (age 65–66)
The Hague, Netherlands
NationalityDutch
Alma materUniversity of Leiden
AwardsJean Leray Award;

The Marie Parijs Award; The Klein Award;

George Winter Award; Huibregtsen Prize; Career Achievement Award;
Scientific career
FieldsBiomedical engineering, biomaterials, tissue engineering
InstitutionsUniversity of Maastricht

Career

Blitterswijk graduated from a bachelor in cell biology at Leiden University and defended his PhD thesis in 1985 at the same university on artificial ceramic middle ear implants under the supervision of Professor Jan Grote[3] and Klaas de Groot,[4] for which he was awarded the Jean Leray young scientist award from the European Society for Biomaterials in 1987.[5] From 1985 to 1996, he worked on hydroxyapatite biomaterials for middle ear implants under the mentorship of Jan Grote[6][7][8] and Klaas De Groot[9][10] at Leiden University.

In 1996, he left Leiden University and co-founded, together with Klaas De Groot, IsoTis BV, a life sciences company focused on bone biomaterials and tissue engineering.

In 1997, he became a professor at University of Twente. Later, he was appointed director of the University of Twente's MIRA Institute for Biomedical Technology and Technical Medicine institute (the institute no longer exists). In collaboration with Jan de Boer, Hemant Unadkat, and Dimitrios Stamatialis, he contributed to the development of a high-throughput assay to design and select micrometer-scale surface textures that could enhance specific biological functions (TopoChip).[11][12]

In 2012, he became a partner of the Life Science Partner (LSP) private investment firm where he invests in private companies and startups related to healthcare innovations.[13]

In 2014, he became a distinguished professor at Maastricht University.[14] Until 2018, he was the director and department chair at the MERLN Institute at Maastricht University. In 2015, he was awarded an ERC Advanced grant that aimed at developing microfabricated and microfluidic cell culture platforms for improving organoids.[15] The conception of this grant application and the research relative to it were done by several principal investigators at Maastricht University.[16][17][18][19][20][21]

Valorization

He has served as CEO of IsoTis.,[22] a company that underwent an Initial Public Offering and was subsequently acquired by Integra LifeSciences.[23][24] In 2018, he became the chairman of the board of directors of Kuros Biosciences.[25]

Teaching

Blitterswijk has been the official supervisor of over 80 PhD candidates who, in their large majority, have worked in the laboratories of other faculty members. He has participated as an editor of four textbooks, including one dedicated to tissue engineering.[26]

Awards
  • Jean Leray award in 1989 for the work in his PhD thesis[5]
  • Professor de Kleijn award in 1989 for the work in his PhD thesis
  • George Winter senior scientist award in 1997[27]
  • Federa award in 2012[28]
  • "Most entrepreneurial scientist" award in 2012[29]
  • Career Achievement award of the EU Chapter of the Tissue Engineering and Regenerative Medicine International Society in 2013[30]
  • Huibregtsen award in 2015[31]
  • ESB Klaas de Groot award in 2021[32]

Ten outstanding publications as a co-author or corresponding author

References
  1. Miron, R.J.; Zhang, Y.F. (August 2012). "Osteoinduction: A Review of Old Concepts with New Standards". Journal of Dental Research. 91 (8): 736–744. doi:10.1177/0022034511435260. ISSN 0022-0345. PMID 22318372. S2CID 209326442.
  2. Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (August 2010). "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13614–9. Bibcode:2010PNAS..10713614Y. doi:10.1073/pnas.1003600107. PMC 2922269. PMID 20643969.
  3. Van Blitterswijk, C. A.; Kuijpers, W.; Daems, W Th; Grote, J. J. (January 1986). "Epithelial Reactions to Hydroxyapatite: An in Vivo and in Vitro Study". Acta Oto-Laryngologica. 101 (3–4): 231–241. doi:10.3109/00016488609132832. ISSN 0001-6489. PMID 3705952.
  4. van Blitterswijk, C.A.; Grote, J.J.; Kuijpers, W.; Daems, W.Th.; de Groot, K. (March 1986). "Macropore tissue ingrowth: a quantitative and qualitative study on hydroxyapatite ceramic". Biomaterials. 7 (2): 137–143. doi:10.1016/0142-9612(86)90071-2. ISSN 0142-9612. PMID 3011138.
  5. "ESB European Society for Biomaterials". www.esbiomaterials.eu. Retrieved 1 June 2020.
  6. Nell, M.J.; Op’t Hof, B.M.; Koerten, H.K.; Grote, J.J. (1999). "Effect of Endotoxin on Cultured Human Middle Ear Epithelium". ORL. 61 (4): 201–205. doi:10.1159/000027671. ISSN 0301-1569. PMID 10450054. S2CID 20788406.
  7. Bakker, D.; van Blitterswijk, C. A.; Hesseling, S. C.; Th. Daems, W.; Kuijpers, W.; Grote, J. J. (June 1990). "The behavior of alloplastic tympanic membranes inStaphylococcus aureus-induced middle ear infection. I. Quantitative biocompatibility evaluation". Journal of Biomedical Materials Research. 24 (6): 669–688. doi:10.1002/jbm.820240604. ISSN 0021-9304. PMID 2163404.
  8. Jj, Grote; D, Bakker; Sc, Hesseling; Ca, van Blitterswijk (September 1991). "New Alloplastic Tympanic Membrane Material". The American Journal of Otology. 12 (5): 329–35. PMID 1665011.
  9. van Blitterswijk, C. A.; Hesseling, S. C.; Grote, J. J.; Koerten, H. K.; de Groot, K. (April 1990). "The biocompatibility of hydroxyapatite ceramic: A study of retrieved human middle ear implants". Journal of Biomedical Materials Research. 24 (4): 433–453. doi:10.1002/jbm.820240403. ISSN 0021-9304. PMID 2161412.
  10. Verheyen, C. C. P. M.; De Wijn, J. R.; Van Blitterswijk, C. A.; De Groot, K. (October 1992). "Evaluation of hydroxylapatite/poly(l-lactide) composites: Mechanical behavior". Journal of Biomedical Materials Research. 26 (10): 1277–1296. doi:10.1002/jbm.820261003. ISSN 0021-9304. PMID 1331112.
  11. Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J (October 2011). "An algorithm-based topographical biomaterials library to instruct cell fate". Proceedings of the National Academy of Sciences of the United States of America. 108 (40): 16565–70. Bibcode:2011PNAS..10816565U. doi:10.1073/pnas.1109861108. PMC 3189082. PMID 21949368.
  12. Baker M (November 2011). "Trying out topographies". Nature Methods. 8 (11): 900. doi:10.1038/nmeth.1760. PMID 22167818. S2CID 5421979.
  13. "LSP van Blitterswijk".
  14. "Distinguished university professors – Research – Maastricht University". maastrichtuniversity.nl. Retrieved 1 February 2018.
  15. "Press release Maastricht University". Maastricht University. 8 April 2016.
  16. Geuens, Thomas; van Blitterswijk, Clemens A.; LaPointe, Vanessa L. S. (30 April 2020). "Overcoming kidney organoid challenges for regenerative medicine". npj Regenerative Medicine. 5 (1): 8. doi:10.1038/s41536-020-0093-4. ISSN 2057-3995. PMC 7192889. PMID 32377381.
  17. Samal, Pinak; Maurer, Philipp; Blitterswijk, Clemens; Truckenmüller, Roman; Giselbrecht, Stefan (29 April 2020). "A New Microengineered Platform for 4D Tracking of Single Cells in a Stem‐Cell‐Based In Vitro Morphogenesis Model". Advanced Materials. 32 (24): 1907966. Bibcode:2020AdM....3207966S. doi:10.1002/adma.201907966. ISSN 0935-9648. PMID 32346909.
  18. Kuhnt, Tobias; Marroquín García, Ramiro; Camarero-Espinosa, Sandra; Dias, Aylvin; ten Cate, A. Tessa; van Blitterswijk, Clemens A.; Moroni, Lorenzo; Baker, Matthew B. (2019). "Poly(caprolactone- co -trimethylenecarbonate) urethane acrylate resins for digital light processing of bioresorbable tissue engineering implants". Biomaterials Science. 7 (12): 4984–4989. doi:10.1039/C9BM01042D. ISSN 2047-4830. PMID 31667486.
  19. Sthijns, Mireille M.J.P.E.; LaPointe, Vanessa L.S.; van Blitterswijk, Clemens A. (1 October 2019). "Building Complex Life Through Self-Organization". Tissue Engineering Part A. 25 (19–20): 1341–1346. doi:10.1089/ten.tea.2019.0208. ISSN 1937-3341. PMC 6784492. PMID 31411111.
  20. Rademakers, Timo; Horvath, Judith M.; Blitterswijk, Clemens A.; LaPointe, Vanessa L.S. (October 2019). "Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization". Journal of Tissue Engineering and Regenerative Medicine. 13 (10): 1815–1829. doi:10.1002/term.2932. ISSN 1932-6254. PMC 6852121. PMID 31310055.
  21. Ooi, Huey Wen; Mota, Carlos; Ten Cate, A. Tessa; Calore, Andrea; Moroni, Lorenzo; Baker, Matthew B. (25 June 2018). "ThiolEne Alginate Hydrogels as Versatile Bioinks for Bioprinting". Biomacromolecules. 19 (8): 3390–3400. doi:10.1021/acs.biomac.8b00696.s001. PMC 6588269. PMID 29939754.
  22. "IsoTis Orthobiologics Archives". SeaSpine.
  23. "IsoTis – Integra Merger". Retrieved 30 September 2018.
  24. "UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934". Retrieved 30 September 2018.
  25. "Professor Clemens van Blitterswijk". Kuros Biosciences. Retrieved 24 May 2020.
  26. Van Blitterswijk, Clemens A.; Thomsen, Peter (2008). Tissue Engineering. ISBN 978-0123708694.
  27. "ESB European Society for Biomaterials". esbiomaterials.eu.
  28. "Federaprijs-winnaars – Federa". federa.org.
  29. "News_van Blitterswijk most entrepreneurial scientist in 2012". Retrieved 1 February 2018.
  30. "TERMIS". Archived from the original on 7 July 2017. Retrieved 1 February 2018.
  31. "Over de prijs". avondwenm.nl.
  32. "ESB European Society for Biomaterials". www.esbiomaterials.eu. Retrieved 15 November 2021.
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