Clifford Wilson (nephrologist)

Clifford Wilson FRCP (1906–1997) was a British nephrologist and professor of medicine.

Clifford Wilson
Born(1906-01-27)27 January 1906
Halifax, Yorkshire
Died10 November 1997(1997-11-10) (aged 91)
Southampton
Known forKimmelstiel-Wilson syndrome[1]
synonym: Kimmelstiel-Wilson disease;
Kimmelstiel-Wilson nodule[2]
synonym: Kimmelstiel-Wilson lesion

Biography

After education at Heath Grammar School in Halifax, Clifford Wilson studied at Balliol College, Oxford, graduating with a first in natural sciences. He then studied medicine at the London Hospital. He qualified MRCS, LRCP in 1931. He graduated BM BCh Oxon in 1933. In 1934, by means of a Rockefeller travelling scholarship, he went to Harvard Medical School, where he worked with the pathologist Paul Kimmelstiel.[3]

In parallel to albuminuria in 1936, discussion on renal lesions observed in patients with diabetes led to the description, by Kimmelstiel and Wilson, of the characteristic nodular fibrotic observed in the diabetic glomeruli (Kimmelstiel and Wilson, 1936b). Kimmelstiel and Wilson introduced the term diabetic nephropathy (DN) to define a clinical syndrome of arterial hypertension, overt proteinuria (or macroalbuminuria), and worsening kidney function (Kimmelstiel and Wilson, 1936a).[4]

Wilson returned to the London Hospital. He graduated DM in 1936.[3] In 1938 he became assistant director of the London Hospital's academic medical unit with Arthur Ellis as the director.[5]

During WWII Wilson served in the RAMC's medical research section and helped to deal with outbreaks of viral hepatitis in the military. In 1946 he succeeded Arthur Ellis as professor of medicine at the University of London. Wilson, with Michael Floyer, Jack Ledingham, and the pathologist Frank Byrom, worked with rats to show how a vicious circle of hypertension can develop — renal damage can cause hypertension, which in turn can cause arteriolar lesions with increased renal damage.[3]

Wilson was elected FRCP in 1951.[3] He was professor of medicine at the University of London (at the London Hospital) from 1946 to 1971, when he retired as professor emeritus. There he was dean of the faculty of medicine from 1968 to 1971 and director of the academic medical unit from 1946 to 1971. He was president of the Renal Association in 1963–1964.[5] In 1967 he gave the Bradshaw Lecture on The cause and prognosis of the nephrotic syndrome.

In 1936 Clifford Wilson married Kathleen Hebden. They had a son and a daughter.[3]

Selected publications

References
  1. Bartolucci, Sue; Forbis, Pat, eds. (2005). Stedman's Medical Eponyms (2nd ed.). Lippincott Williams & Wilkins. p. 380. ISBN 9780781754439.
  2. "Nodular glomerulosclerosis, microscopic - Renal Pathology". The Internet Pathology Library for Medical Education hosted by the University of Utah Eccles Health Science Library.
  3. "Clifford Wilson". Munk's Roll, Volume X, Lives of the Fellows, Royal College of Physicians.
  4. Turner, Neil, ed. (2015). "Chapter 149. The patient with diabetes mellitus by Luigi Gnudi, Giorgio Gentile, and Piero Ruggenenti". In: Oxford Textbook of Clinical Nephrology. Oxford University Press. pp. 1199–1247. ISBN 978-0-19-959254-8.
  5. Cohen, R. D. (19 November 1997). "Obituary: Professor Clifford Wilson". The Independent.
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