Cobyrinate a,c-diamide synthase

Cobyrinate a,c-diamide synthase (EC ), cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction[1]

2 ATP + cobyrinate + 2 L-glutamine + 2 H2O 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)
(1a) ATP + cobyrinate + L-glutamine + H2O ADP + phosphate + cobyrinate c-monamide + L-glutamate
(1b) ATP + cobyrinate c-monamide + L-glutamine + H2O ADP + phosphate + cobyrinate a,c-diamide + L-glutamate
Cobyrinate a,c-diamide synthase
Identifiers
EC no.6.3.5.11
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme is a glutamine amidotransferase, part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

References

  1. Fresquet V, Williams L, Raushel FM (August 2004). "Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2". Biochemistry. 43 (33): 10619–27. doi:10.1021/bi048972x. PMID 15311923.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.