Coenzyme F420-1:gamma-L-glutamate ligase

Coenzyme F420-1:γ-L-glutamate ligase (EC 6.3.2.34, F420:gamma-glutamyl ligase, CofE-AF, MJ0768, CofE) is an enzyme with systematic name L-glutamate:coenzyme F420-1 ligase (GDP-forming).[1][2] This enzyme catalyses the following chemical reaction

GTP + coenzyme F420-1 + L-glutamate GDP + phosphate + coenzyme γ-F420-2
Coenzyme F420-1:γ-L-glutamate ligase
Identifiers
EC no.6.3.2.34
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This protein catalyses the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions.

References

  1. Li H, Graupner M, Xu H, White RH (August 2003). "CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii". Biochemistry. 42 (32): 9771–8. doi:10.1021/bi034779b. PMID 12911320.
  2. Nocek B, Evdokimova E, Proudfoot M, Kudritska M, Grochowski LL, White RH, Savchenko A, Yakunin AF, Edwards A, Joachimiak A (September 2007). "Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non-ribosomal peptide synthases". Journal of Molecular Biology. 372 (2): 456–69. doi:10.1016/j.jmb.2007.06.063. PMC 2678844. PMID 17669425.
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