Collectin-12

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.[5]

COLEC12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOLEC12, CLP1, NSR2, SCARA4, SRCL, collectin subfamily member 12
External IDsOMIM: 607621 MGI: 2152907 HomoloGene: 34248 GeneCards: COLEC12
Orthologs
SpeciesHumanMouse
Entrez

81035

140792

Ensembl

ENSG00000158270

ENSMUSG00000036103

UniProt

Q5KU26

Q8K4Q8

RefSeq (mRNA)

NM_030781
NM_130386

NM_130449

RefSeq (protein)

NP_569057

NP_569716

Location (UCSC)Chr 18: 0.32 – 0.5 MbChr 18: 9.71 – 9.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].

References

  1. GRCh38: Ensembl release 89: ENSG00000158270 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036103 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Collectin subfamily member 12". Retrieved 2019-12-24.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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