Estradiol/norethisterone acetate

Estradiol/norethisterone acetate
Combination of
Estradiol	Estrogen
Norethisterone acetate	Progestogen
Clinical data
Trade names	Activella, Amabelz, CombiPatch, others
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a601041
Routes of; administration	By mouth
ATC code	G03FA01 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	77728-33-7 ;
ChemSpider	none;
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Estradiol/norethisterone acetate (E2/NETA), sold under the brand name Activella among others, is a combination of estradiol (E2) and norethisterone acetate (NETA) which is used in the treatment of vasomotor symptoms, vulvar and vaginal atrophy, and osteoporosis[1] associated with menopause.[2] Activella specifically is marketed by Novo Nordisk and is supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethisterone acetate. CombiPatch is a combination of estradiol and NETA provided as a transdermal patch.[2]

References

Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, et al. (October 2002). "Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study". Journal of Bone and Mineral Research. 17 (10): 1904–12. doi:10.1359/jbmr.2002.17.10.1904. PMID 12369794. S2CID 29312298.
"CombiPatch (estradiol/norethindrone acetate transdermal system) Prescribing Information" (PDF). Noven Pharmaceuticals, Inc. U.S. Food and Drug Administration.

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