Comorbidity–polypharmacy score

In medicine, the Comorbidity–polypharmacy score (CPS) is a measure of overall severity of comorbidities.[1] It is defined as the simple sum of the number of known comorbidities (concurrent conditions) and pre-admission medications taken by the patient (polypharmacy), as a surrogate for the “intensity” of the comorbidities.[2]

This score has been tested and validated extensively in the trauma population, demonstrating good correlation with mortality, morbidity, triage, and hospital readmissions.[3][4][5] Increasing levels of CPS were associated with significantly lower 90-day survival in the original study of the score in trauma population.[3]

Comparison with other comorbidity measures

The test is similar to the Charlson Comorbidity Index (CCI), but CPS also considers the number of medications taken, which is not a parameter in CCI. Additionally, CPS considers a wider range of comorbidities than CCI, and assigns the same weight to each.[2] A study comparing the two metrics found that CCI was a better predictor of mortality than CPS in older trauma patients.[6]

See also

References
  1. Khanh, Linh Ngo; Helenowski, Irene B.; Hoel, Andrew W.; Ho, Karen J. (2020-11-01). "The Comorbidity-Polypharmacy Score is an Objective and Practical Predictor of Outcomes and Mortality after Vascular Surgery". Annals of Vascular Surgery. 69: 206–216. doi:10.1016/j.avsg.2020.05.055. ISSN 0890-5096. PMID 32502672. S2CID 219398575.
  2. Stawicki, Stanislaw P.; Kalra, Sarathi; Jones, Christian; Justiniano, Carla F.; Papadimos, Thomas J.; Galwankar, Sagar C.; Pappada, Scott M.; Feeney, John J.; Evans, David C. (2015). "Comorbidity polypharmacy score and its clinical utility: A pragmatic practitioner's perspective". Journal of Emergencies, Trauma, and Shock. 8 (4): 224–231. doi:10.4103/0974-2700.161658. ISSN 0974-2700. PMC 4626940. PMID 26604529.
  3. Evans, DC; Cook, CH; Christy, JM (August 2012). "Comorbidity–polypharmacy scoring facilitates outcome prediction in older trauma patients". J Am Geriatr Soc. 60 (8): 1465–70. doi:10.1111/j.1532-5415.2012.04075.x. PMID 22788674. S2CID 40542659.
  4. Justiniano, CF; Coffey, RA; Evans, DC (Jan 2015). "Comorbidity–polypharmacy score predicts in-hospital complications and the need for discharge to extended care facility in older burn patients". J Burn Care Res. 36 (1): 193–96. doi:10.1097/bcr.0000000000000094. PMID 25559732. S2CID 3677354.
  5. Justiniano, CF; Evans, DC; Cook, CH (May 2013). "Comorbidity–polypharmacy score: a novel adjunct in post-emergency department trauma triage". J Surg Res. 181 (1): 16–19. doi:10.1016/j.jss.2012.05.042. PMC 3717608. PMID 22683074.
  6. Chua, Mui Teng; Pan, Darius Shaw Teng; Lee, Ming Zhou; Thajudeen, Mohammed Zuhary; Rahman, Mohamed Madeena Faizur; Sheth, Irfan Abdulrahman; Ong, Victor Yeok Kein; Tang, Jonathan Zhe Ying; Wee, Choon Peng Jeremy; Kuan, Win Sen (April 2023). "Comparing Comorbidity Polypharmacy Score and Charlson Comorbidity Index in predicting outcomes in older trauma patients". Injury. 54 (4): 1113–1118. doi:10.1016/j.injury.2023.02.031. ISSN 1879-0267. PMID 36822915. S2CID 257002026.


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