Contactin 2

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.[5][6][7]

CNTN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNTN2, AXT, FAME5, TAG-1, TAX, TAX1, contactin 2, transient axonal glycoprotein-1
External IDsOMIM: 190197 MGI: 104518 HomoloGene: 3720 GeneCards: CNTN2
Orthologs
SpeciesHumanMouse
Entrez

6900

21367

Ensembl

ENSG00000184144

ENSMUSG00000053024

UniProt

Q02246

Q61330

RefSeq (mRNA)

NM_005076
NM_001346083

NM_011531
NM_177129

RefSeq (protein)

NP_001333012
NP_005067

NP_796103

Location (UCSC)Chr 1: 205.04 – 205.08 MbChr 1: 132.44 – 132.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.[7]

Interactions

CNTN2 has been shown to interact with CNTNAP2[8] and NFYB.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000184144 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053024 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tsiotra PC, Karagogeos D, Theodorakis K, Michaelidis TM, Modi WS, Furley AJ, Jessell TM, Papamatheakis J (Dec 1993). "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1". Genomics. 18 (3): 562–7. doi:10.1016/S0888-7543(05)80357-X. PMID 8307567.
  6. Yoshihara Y, Kawasaki M, Tamada A, Nagata S, Kagamiyama H, Mori K (Sep 1995). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily". Journal of Neurobiology. 28 (1): 51–69. doi:10.1002/neu.480280106. PMID 8586965.
  7. "Entrez Gene: CNTN2 contactin 2 (axonal)".
  8. Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi F, Watanabe K, Soliven B, Girault JA, Karagogeos D (Sep 2003). "Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers". The Journal of Cell Biology. 162 (6): 1161–72. doi:10.1083/jcb.200305078. PMC 2172849. PMID 12975355.
  9. Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Molecular and Cellular Biology. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.

Further reading


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