Cortical minicolumn

A cortical minicolumn (also called cortical microcolumn[1]) is a vertical column through the cortical layers of the brain. Neurons within the microcolumn "receive common inputs, have common outputs, are interconnected, and may well constitute a fundamental computational unit of the cerebral cortex".[2][3] Minicolumns comprise perhaps 80–120 neurons, except in the primate primary visual cortex (V1), where there are typically more than twice the number. There are about 2×108 minicolumns in humans.[4] From calculations, the diameter of a minicolumn is about 28–40 μm.[2] Minicolumns grow from progenitor cells within the embryo and contain neurons within multiple layers (2–6) of the cortex.[5]

Visualization of cortical minicolumns within a macrocolumn

Many sources support the existence of minicolumns, especially Mountcastle,[2] with strong evidence reviewed by Buxhoeveden and Casanova[6] who conclude "... the minicolumn must be considered a strong model for cortical organization" and "[the minicolumn is] the most basic and consistent template by which the neocortex organizes its neurones, pathways, and intrinsic circuits".

Cells in 50 μm minicolumn all have the same receptive field; adjacent minicolumns may have different fields.[7]

Number of neurons

Estimates of number of neurons in a minicolumn range from 80–100 neurons.[6][2][8]

Jones[7] describes a variety of observations that may be interpreted as mini- or micro-columns and gives example numbers from 11 to 142 neurons per minicolumn.

Number of minicolumns

Estimates of the number of neurons in cortex or in neocortex are on the order of 2×1010.[9][10] Most[11] (perhaps 90%) of cortical neurons are neocortical neurons.

Johansson and Lansner[4] use an estimate of 2×1010 neurons in the neocortex and an estimate of 100 neurons per minicolumn, yielding an estimate of 2×108 minicolumns.

Sporns et al. give an estimate of 2×107 – 2×108 minicolumns.[12]

Size of minicolumns

The minicolumn measures of the order of 40–50 μm in transverse diameter;[2][6] 35–60 μm; 50 μm with 80 μm spacing, or 30 μm with 50 μm. Larger sizes may not be of human minicolumns, for example macaque monkey V1 minicolumns are 31 μm diameter, with 142 pyramidal cells — 1270 columns per mm2. Similarly, the cat V1 has much bigger minicolumns, ~56 μm.

The size can also be calculated from area considerations. If cortex (both hemispheres) is 1.27×1011 μm2 then if there are 2×108 minicolumns in the neocortex then each is 635 μm2, giving a diameter of 28 μm (if the cortex area were doubled to the commonly quoted value, this would rise to 40 μm). Johansson and Lansner[4] do a similar calculation and arrive at 36 μm (p51, last para).

Downwards projecting axons in minicolumns are ≈10 μm in diameter, periodicity and density similar to those within the cortex, but not necessarily coincident.

See also

References
  1. Cruz, Luis; Buldyrev, Sergey; Peng, Shouyong; Roe, Daniel; Urban, Brigita; Stanley, HE; Rosene, Douglas (February 2005). "A statistically based density map method for identification and quantification of regional differences in microcolumnarity in the monkey brain". Journal of Neuroscience Methods. 141 (3): 321–332. doi:10.1016/j.jneumeth.2004.09.005. PMID 15661314. S2CID 6316809 – via Elsevier Science Direct.
  2. Mountcastle, Vernon (July 1957). "Modality and topographic properties of single neurons of cat's somatic sensory cortex". Journal of Neurophysiology. 20 (4): 408–34. doi:10.1152/jn.1957.20.4.408. PMID 13439410.
  3. Bennett, Max (July 2020). "An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex". Frontiers in Neural Circuits. 14: 40. doi:10.3389/fncir.2020.00040. PMC 7416357. PMID 32848632.
  4. Johansson, Christopher; Lansner, Anders (2007). "Towards cortex sized artificial neural systems". Neural Networks. 20 (1): 48–61. doi:10.1016/j.neunet.2006.05.029. PMID 16860539.
  5. Jeff Hawkins, Sandra Blakeslee On Intelligence p. 94
  6. Buxhoeveden, Daniel P.; Casanova, Manuel F. (May 2002). "The minicolumn hypothesis in neuroscience". Brain. 125 (Pt 5): 935–951. doi:10.1093/brain/awf110. ISSN 0006-8950. PMID 11960884.
  7. Jones, Edward G. (2000-05-09). "Microcolumns in the cerebral cortex". Proceedings of the National Academy of Sciences. 97 (10): 5019–5021. Bibcode:2000PNAS...97.5019J. doi:10.1073/pnas.97.10.5019. ISSN 0027-8424. PMC 33979. PMID 10805761.
  8. Sporns O, Tononi G, Kötter R. The human connectome: A structural description of the human brain. PLoS Comput. Biol. 2005 Sep1(4):e42.
  9. Pakkenberg B., Gundersen H. J. G. (1997). "Neocortical Neuron Number in Humans: Effect of Sex and Age". The Journal of Comparative Neurology. 384 (2): 312–320. doi:10.1002/(sici)1096-9861(19970728)384:2<312::aid-cne10>3.3.co;2-g. PMID 9215725.
  10. Azevedo, Frederico A.C.; Carvalho, Ludmila R.B.; Grinberg, Lea T.; Farfel, José Marcelo; Ferretti, Renata E.L.; Leite, Renata E.P.; Filho, Wilson Jacob; Lent, Roberto; Herculano-Houzel, Suzana (2009). "Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain" (PDF). J. Comp. Neurol. 513 (5): 532–541. doi:10.1002/cne.21974. PMID 19226510. S2CID 5200449.
  11. Claudia Krebs MD PhD, Joanne Weinberg PhD, Elizabeth Akesson MSc. Lippincott’s Illustrated Reviews: Neuroscience, accessed Nov 10 2013. Chapter 13, II.A, "Histological organization of the cortex"
  12. Sporns O, Tononi G, Kötter R. The human connectome: A structural description of the human brain. PLoS Comput. Biol. 2005 Sep1(4):e42
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