Cortisol O-acetyltransferase

In enzymology, a cortisol O-acetyltransferase (EC 2.3.1.27) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + cortisol CoA + cortisol 21-acetate
cortisol O-acetyltransferase
Identifiers
EC no.2.3.1.27
CAS no.9076-48-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are acetyl-CoA and cortisol, whereas its two products are CoA and cortisol 21-acetate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:cortisol O-acetyltransferase. Other names in common use include cortisol acetyltransferase, corticosteroid acetyltransferase, and corticosteroid-21-O-acetyltransferase.

References

    • Thomas PJ (October 1968). "Cortisol acetyltransferase from baboon brain". The Biochemical Journal. 109 (4): 695–6. doi:10.1042/bj1090695. PMC 1186958. PMID 4971640.


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