Corydaline synthase

In enzymology, a corydaline synthase (EC 2.1.1.147) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ S-adenosyl-L-homocysteine + corydaline + 2 NADP+
corydaline synthase
Identifiers
EC no.2.1.1.147
CAS no.155807-67-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 4 substrates of this enzyme are S-adenosyl methionine, palmatine, NADPH, and H+, whereas its 3 products are S-adenosylhomocysteine, corydaline, and NADP+.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.

References

    • Rueffer M, Bauer W, Zenk MH (1994). "The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro". Can. J. Chem. 72: 170–175. doi:10.1139/v94-026.


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