Cruentaren

Cruentarens are a group of macrolides secreted by the myxobacteria Byssovorax cruenta.[1] There are two isomers (cruentaren A and B) have been isolated.[2] They each have a molecular formula of C33H51NO8 and molecular weight 589 g/mol. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro,[3] including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.

Chemical structure of cruentaren A

References
  1. Kunze, Brigitte; Heinrich Steinmetz; Gerhard Höfle; Markus Huss; Helmut Wieczorek; Hans Reichenbach (2006). "Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (Myxobacteria) with inhibitory effect on mitochondrial ATPase activity : Fermentation and biological properties". Journal of Antibiotics. 59 (10): 664–668. doi:10.1038/ja.2006.89. ISSN 0021-8820. PMID 17191683.
  2. Jundt, Larissa; Steinmetz, Heinrich; Luger, Peter; Weber, Manuela; Kunze, Brigitte; Reichenbach, Hans; Höfle, Gerhard (2006). "Isolation and Structure Elucidation of Cruentarens A and B — Novel Members of the Benzolactone Class of ATPase Inhibitors from the Myxobacterium Byssovorax cruenta". European Journal of Organic Chemistry (22): 5036–5044. doi:10.1002/ejoc.200600421.
  3. Kunze, Brigitte; Sasse, Florenz; Wieczorek, Helmut; Huss, Markus (2007). "Cruentaren A, a highly cytotoxic benzolactone from Myxobacteriais a novel selective inhibitor of mitochondrial F1-ATPases". FEBS Letters. 581 (18): 3523–3527. doi:10.1016/j.febslet.2007.06.069. PMID 17624334.
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