Cucurbitacin Delta23-reductase
In enzymology, a cucurbitacin Delta23-reductase (EC 1.3.1.5) is an enzyme that catalyzes the chemical reaction
- 23,24-dihydrocucurbitacin + NAD(P)+ cucurbitacin + NAD(P)H + H+
cucurbitacin delta23-reductase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.1.5 | ||||||||
CAS no. | 37256-38-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are 23,24-dihydrocucurbitacin, NAD+, and NADP+, whereas its 4 products are cucurbitacin, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 23,24-dihydrocucurbitacin:NAD(P)+ Delta23-oxidoreductase. This enzyme is also called NAD(P)H: cucurbitacin B Delta23-oxidoreductase. It employs one cofactor, manganese.
References
- Schabort JC, Potgieter DJ (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. II Cofactor requirements, enzyme kinetics, substrate specificity and other characteristics". Biochim. Biophys. Acta. 151 (1): 47–53. doi:10.1016/0005-2744(68)90159-9. PMID 4384331.
- Schabort JC, Potgieter DJ, de Villiers V (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. I. Assay methods, isolation and purification". Biochim. Biophys. Acta. 151 (1): 33–46. doi:10.1016/0005-2744(68)90158-7. PMID 5640163.
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