CCNC (gene)

Cyclin-C is a protein that in humans is encoded by the CCNC gene.[5][6]

CCNC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCNC, CycC, cyclin C, hSRB11, SRB11
External IDsOMIM: 123838 MGI: 1858199 HomoloGene: 3803 GeneCards: CCNC
Orthologs
SpeciesHumanMouse
Entrez

892

51813

Ensembl

ENSG00000112237

ENSMUSG00000028252

UniProt

P24863

Q62447

RefSeq (mRNA)

NM_001013399
NM_005190
NM_001363537

NM_001122982
NM_001290420
NM_001290422
NM_016746

RefSeq (protein)

NP_001013417
NP_005181
NP_001350466

NP_001116454
NP_001277349
NP_001277351
NP_058026

Location (UCSC)Chr 6: 99.54 – 99.57 MbChr 4: 21.73 – 21.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha[7] and Cyclin-dependent kinase 8.[7][8][9][10][11]

References

  1. GRCh38: Ensembl release 89: ENSG00000112237 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028252 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.
  6. "Entrez Gene: CCNC cyclin C".
  7. Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
  8. Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135.
  9. Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. ISSN 0270-7306. PMC 109120. PMID 9710619.
  10. Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
  11. Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034.

Further reading


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